The A534 Sandbach Road was closed after two vehicles a silver Peugeot 406 and Ford transit van collided.
The incident happened near Congleton Cheshire at around 1.15 on Friday.
The driver of the Peugeot a 71 year old man suffered serious injuries to his legs and his passenger from Crewe a 13 year old male who suffered head injuries in the crash had to be airlifted to Leighton Hospital.
The 28 year old man from Bolton who was driving the transit van is believed to have suffered head and spinal injuries was taken to Macclesfield District Hospital. Police closed the road to carry out thorough investigation.
Anyone who may have witnessed the accident or has information should call Cheshire Police on 0845 4580000.
If you or a member of your family have been involved in a road traffic accident that was not your fault contact Amanda Cunliffe Solicitors on 0800 2800 976 for help with your personal injury claim for compensation.